Publications

Cancer Virotherapy

In the last two decades, viral vector-based therapies are gaining increasing attention as a promising strategy for cancer treatment. Studies in this field have explored the administration of viral vectors as agents for therapeutic vaccines, gene therapy and more recently as oncolytic therapeutics.
> Read the systematic analysis on clinical studies assessing safety and efficacy of Onco-virotherapy here.
> Get insight on various mechanisms of therapeutic resistance that impairs virotherapy.
> A sneak-peek of ongoing work on how tumor‐derived extracellular vesicles boost melanoma response to oncolytic therapy (PT07.14.)

Therapeutic Resistance

Therapeutic resistance has been studied as a mechanism that allows the therapeutic-target to escape and evolve against the treatment, for example in the context of antibiotic resistance by pathogenic bacteria and resistance by tumors towards radiotherapy, chemotherapy, or immunotherapy.
> Visualize the spatial dynamics of oncolytic virotherapy in presence of virus-resistant tumor cells through a computational model. (preprint)
> Get insight on various mechanisms of therapeutic resistance that impairs virotherapy.
> Read about the role of tumor extracellular vesicles in tumor progression and therapy resistance.

Immunoglobulins & Unfolded Protein Response

B cells orchestrate pro‐survival and pro‐apoptotic inputs to translate, fold, sort, secrete and recycle immunoglobulins, however B cells in some immunodeficient patients are predisposed to an overload of abnormally processed, misfolded immunoglobulins. We studied how dysregulation of unfolded protein response (UPR) in these B cells compared to the healthy control correlates with the disease phenotype. Read more.

Science Bites

My ‘bite-sized’ articles for general audience, approximately five minute reads, that share what is exciting in the field of Science.
> Read about evolutionary biology in bite-sized pieces @EvoBites
> Read about cancer biology in bite-sized pieces @OncoBites
> A chapter on Tumor Immunology (PDF in Portuguese) @CancerPlato

Synthetic Biology Projects and iGEM

Synthetic Biology is a field of Science focused on (re)designing biology using principles of engineering. The International Genetically Engineered Machine (iGEM) Foundation is an independent, non-profit organization dedicated to the advancement of synthetic biology, education and competition, and the development of an open community and collaboration. Find my contributions here.

Microscopy Images

For everyone curious in the microscopic world, have a look here.

Publications by year

Articles can also be accessed via: PUBMED

2022

Modelling the spatial dynamics of oncolytic virotherapy in the presence of virus-resistant tumor cells. (preprint). GitHub link to the model: www.github.com/rugtres/ovr
Bhatt DK, Janzen T, Daemen T, Weissing FJ. 2022, Biorxiv. (Access PDF)

Poster presented at ISEV 2022: Tumor‐derived extracellular vesicles boost melanoma response to oncolytic therapy (Abstract view of poster #PT07.14.). (Access PDF)
D. Bhatt; S. Bustos; T. Daemen; R. Chammas; L. N. S. Andrade

Book chapter: Resposta Imune e Evasão (Tumor immune response and evasion). 2022, ONCOLOGIA Da Molécula à Clínica, published at CancerPlato . (Access PDF in Portuguese)

2021

Resistance Mechanisms Influencing Oncolytic Virotherapy, a Systematic Analysis.
Bhatt DK, Chammas R, Daemen T. 2021, Vaccines, 9, 1166. (Access PDF)

A systematic analysis on the clinical safety and efficacy of Onco-Virotherapy.
DK Bhatt, L Wekema, LRC Barros, R Chammas, T Daemen. 2020, MolTher. Oncolytics. (Access PDF)

Tumor-derived extracellular vesicles: modulation of cellular functional dynamics in tumor microenvironment and its clinical implications.
NL Santos, SO Bustos, DK Bhatt, R Chammas, LNS Andrade Frontiers in Cell and Developmental Biology, 2391. (Access PDF)

Comparative analysis of three studies measuring fluorescence from engineered bacterial genetic constructs.
Beal J, Baldwin GS, Farny NG, Gershater M, Haddock-Angelli T, et al. and iGEM Interlab Study Contributors (2021), PLOS ONE 16(6): e0252263. (Access PDF)

2020

Therapeutic Vaccines and Cancer Immunotherapy.
Bhatt D, Daemen T. 2020, Vaccines (Basel);8(4):E596. (Access PDF)

Cellular Adaptation Relies on Regulatory Proteins Having Episodic Memory: Proteins Modulate Cell Metabolism and Reproduction by Remembering, Transmitting, and Using Data on the Environment.
Stan RC, Bhatt DK, de Camargo MM. 2020. Bioessays 42: e1900115 (Access PDF)

Chemical chaperones reverse early suppression of regulatory circuits during unfolded protein response in B cells from common variable immunodeficiency patients.
Bhatt D, Stan RC, Pinhata R, Machado M, et al. 2020. Clin. Exp. Immunol. 200: 73–86. (Access PDF)

Robust Estimation of Bacterial Cell Count from Optical Density.
Beal J, Farny NG, Haddock-Angelli T, Selvarajah V, et al. and iGEM Interlab Study Contributors. 2020, Nat.Comm.Bio. (Access PDF)